Biological challenges for regeneration of the degenerated disc using cellular therapies
نویسندگان
چکیده
1 Department of Orthopaedics, Aarhus University Hospital, Denmark; 2 INSERM UMR 1229, Regenerative Medecine and Skeleton, University of Nantes, France; 3 Spinal Studies and ISTM (Keele University), Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK; 4 Department of Orthopaedics, Tokai University Hospital, Japan; 5 Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK. *current address: Cardiovascular Research Institute, University of California, San Francisco, CA, USA. Correspondence: [email protected] Submitted 2016-03-15. Accepted 2017-01-07.
منابع مشابه
Repair and Regenerative Therapies of the Annulus Fibrosus of the Intervertebral Disc.
Degeneration of the intervertebral disc is implicated as the main cause of low back pain. Current treatment strategies for degenerative disc disease, such as conservative treatments and surgeries, only relieve the symptoms of low back pain without treating the causes of underlying degeneration. Surgical treatments cannot reverse the degeneration of the intervertebral disc degeneration, and may ...
متن کاملAdipose-derived stem cells improve the viability of nucleus pulposus cells in degenerated intervertebral discs.
Patients with degenerative disc disease (DDD) experience serious clinical symptoms, including chronic low back pain. A series of therapies have been developed to treat DDD, including physical therapy and surgical treatment. However, the therapeutic effect of such treatments has remained insufficient. Recently, stem cell‑based therapy, in which stem cells are injected into the nucleus pulposus i...
متن کاملType-2 Fuzzy Hybrid Expert System For Diagnosis Of Degenerative Disc Diseases
One-third of the people with an age over twenty have some signs of degenerated discs. However, in most of the patients the mere presence of degenerative discs is not a problem leading to pain, neurological compression, or other symptoms. This paper presents an interval type-2 fuzzy hybrid rule-based system to diagnose the abnormal degenerated discs where pain variables are represented by interv...
متن کاملLentiviral-mediated RNAi targeting caspase-3 inhibits apoptosis induced by serum deprivation in rat endplate chondrocytes in vitro
Current studies find that degenerated cartilage endplates (CEP) of vertebrae, with fewer diffusion areas, decrease nutrient supply and accelerate intervertebral disc degeneration. Many more apoptotic cells have been identified in degenerated than in normal endplates, and may be responsible for the degenerated grade. Previous findings suggest that inhibition of apoptosis is one possible approach...
متن کاملEnhancing intervertebral disc repair and regeneration through biology: platelet-rich plasma as an alternative strategy
Intervertebral disc degeneration (IDD) is a common orthopedic disease associated with mechanical changes that may result in significant pain. Current treatments for IDD mainly depend on conservative therapies and spinal surgeries that are only able to relieve the symptoms but do not address the cause of the degeneration and even accelerate the degeneration of adjacent segments. This has prompte...
متن کامل